Contradictory results were reported for the prognostic role of CpG island methylator phenotype (CIMP) among colorectal cancer (CRC) patients. analyses of different CIMP panels in the same large study populations are needed to further clarify the role of CIMP definitions and to find 501-94-0 IC50 out how methylation information can best be used to predict CRC prognosis and response to specific CRC therapies. Electronic supplementary material The online version of this article (doi:10.1186/s13148-016-0191-8) contains supplementary material, which is available to authorized users. value and hazard ratio (HR) and 95?% confidence intervals (95?% CI)) including associations with overall survival (OS), disease-specific survival (DSS), disease-free survival (DFS), and recurrence-free survival (RFS). 501-94-0 IC50 Given the importance of potential confounding factors, we extracted data from the most comprehensively adjusted model only when results from different models were reported. If no adjusted results were available, we included the unadjusted results. Results Literature search result The literature search found 394 articles in total (Fig.?1). After removal of 125 duplicates, 269 titles and abstracts were screened for potentially relevant articles. Following exclusion of 193 non-relevant articles and 31 non-original articles, 45 studies were left for full-text review, and two additional studies related to the topic were found by cross-referencing. These 47 studies included studies investigating the association between CIMP and prognosis of CRC (value only. (DOCX 22 kb) Notes This paper was supported by the following grant(s): China Scholarship Council. Footnotes Competing interests The authors declare that they have no competing interests. Authors contributions HB, MH, and MJ designed the study. MJ and XG extracted the data. MJ wrote the manuscript. HB, MH, and YZ revised the manuscript. All authors read and approved the final manuscript. Contributor Information Min Jia, Email: firstname.lastname@example.org. Xu Gao, Email: email@example.com. Yan Shh Zhang, Email: 501-94-0 IC50 firstname.lastname@example.org. Michael Hoffmeister, Email: email@example.com. Hermann Brenner, Email: firstname.lastname@example.org..